Release height takes the first few degrees
The 45-degree answer assumes you release at ground level, in still air, with the same speed available at every angle. None of that holds. Release a shot from 2.15 m up and the ballistic optimum drops to about 42 degrees on its own. Aerodynamics and the limits of the human body then take another 3 to 10 degrees off, event by event. Implement weight changes the speed available at every angle, and the legal discus weights are listed by level.

